University of Witten / Herdecke . A study by scientists shows: Not for chemotherapy and radiation therapy triggers the change, but the brain is changed by the tumor. Change the metabolism in brain tumors adjacent healthy brain: This has a team of researchers led by Dr. Martin Busch at the Department of Radiology and Microtherapy Professor Dr. Dietrich Grönemeyer at the University of Witten / Herdecke in a recently published study (see below) demonstrated. With the help of magnetic resonance spectroscopy, the scientists could show that the biochemistry into "tumorous" different areas of the brain in brain tumor patients from the norm. For the study, 135 single voxel "spectra of 43 brain tumor patients and in 129 spectra in 52 healthy subjects were created.
"With the so-called single-voxel images we can investigate the biochemical composition of a predetermined portion of the brain. So we 'healthy' areas of the brain tumor patients have compared with those of healthy volunteers and found significant differences. The interpretation of the observation is not so simple, "Dr. Martin Busch describes his research. Already, the scientists can rule out that the visible changes caused by chemotherapy and / or radiation therapy can be triggered. "This was our first hypothesis that the so very tissue-damaging therapies could be the reason for the changes. But we were able to exclude with statistical methods. "In the future, the data of spectroscopy will be correlated with biochemical parameters (eg tumor markers in the blood), so as to isolate the causes of the changes.
For specialists: The spectra of both groups were only due to the relative concentration of N-Acetalaspartat be distinguished well and also was a statistically significant difference by myoinositol possible. The area under the curve of receiver operating characteristic "for both metabolites was 0.86 and 0.62. The linear discriminant analysis was to predict whether patients belonged to a spectrum or group of subjects, possible with an accuracy of well over 80%. That indicates a general change in metabolism in the brain tumor patient who could possibly by migration of tumor cells into healthy areas of the brain are activated.
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