Prolonged action of noradrenaline improves motor function in stroke patients
MPG (03/07/2011)
remains impaired in many patients after a stroke, the fine motor skills. The chemical neurotransmitter norepinephrine can obviously reduce these deficits. This results in a new therapeutic approach to rehabilitation would derive from a stroke. (Annals of Neurology, 2010). In the study of Christian Grefkes from the Max Planck Institute for Neurological Research, the in collaboration with the Institute of Neuroscience and Medicine at the Research Centre Jülich and was the Neurology Clinic of the University Hospital of Cologne, completed eleven o'clock stroke patients (42 to 74 years old) with motor deficits various motor tasks, in which determines the maximum grip strength and finger tapping rate or pointing movements were performed.
this influenced the research period for which the chemical messenger, norepinephrine, of course, distributed by the administration of reboxetine (RBX). This substance slows down the recovery of the transmitter in the neural cell memory and extend its stimulating effect on the coupling in the motor cortical network. In the control condition, the researchers gave patients an identical-looking tablet with no active ingredient (placebo).
induced behavioral level, the prolonged residence time of noradrenaline particularly an improvement in simple motor tests: while the grip force of the affected hand, while the average quadrupled, doubled the finger tapping rate - one both for patients and for neurologists remarkable improvement. The improvements were related to motor cortical level with normalization of previously abnormal increased brain activity to detect such as magnetic resonance tomographic brain scans could - especially in the motor areas of affected hemisphere. These processes were associated with increased communication efficiency between the hand area and the upstream motor control centers. The young scientist Christian Grefkes is optimistic: "The findings of our study could prove to be a starting point of a new, promising therapeutic approach in order to correct disturbances in brain networks and improve hand motor function after stroke. The intention is to reboxetine testing of a larger group of patients over a period of several weeks to assess the sustainability of improvement effects.
Original
E. Ling Wang, Gereon R. Fink, Svenja Diekhoff, Anne K. Rehm, Simon B. Eickhoff and Christian Grefkes. Noradrenergic Enhancement Improve Engine Network Connectivity in Stroke Patients. Ann Neurol. 2010 Dec 28; DOI/10.1002/ana.22237
Contact: Dr. Christian
Grefkes,
Leiter who Forschungsgruppe "Neuromodulation & Neurorehabilitation"
Max-Planck-Institut für neurologische Forschung, Cologne
E-Mail: grefkes @ nf . mpg.de
this influenced the research period for which the chemical messenger, norepinephrine, of course, distributed by the administration of reboxetine (RBX). This substance slows down the recovery of the transmitter in the neural cell memory and extend its stimulating effect on the coupling in the motor cortical network. In the control condition, the researchers gave patients an identical-looking tablet with no active ingredient (placebo).
induced behavioral level, the prolonged residence time of noradrenaline particularly an improvement in simple motor tests: while the grip force of the affected hand, while the average quadrupled, doubled the finger tapping rate - one both for patients and for neurologists remarkable improvement. The improvements were related to motor cortical level with normalization of previously abnormal increased brain activity to detect such as magnetic resonance tomographic brain scans could - especially in the motor areas of affected hemisphere. These processes were associated with increased communication efficiency between the hand area and the upstream motor control centers. The young scientist Christian Grefkes is optimistic: "The findings of our study could prove to be a starting point of a new, promising therapeutic approach in order to correct disturbances in brain networks and improve hand motor function after stroke. The intention is to reboxetine testing of a larger group of patients over a period of several weeks to assess the sustainability of improvement effects.
Original
E. Ling Wang, Gereon R. Fink, Svenja Diekhoff, Anne K. Rehm, Simon B. Eickhoff and Christian Grefkes. Noradrenergic Enhancement Improve Engine Network Connectivity in Stroke Patients. Ann Neurol. 2010 Dec 28; DOI/10.1002/ana.22237
Contact: Dr. Christian
Grefkes,
Leiter who Forschungsgruppe "Neuromodulation & Neurorehabilitation"
Max-Planck-Institut für neurologische Forschung, Cologne
E-Mail: grefkes @ nf . mpg.de
Quelle: IDW
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